Prolozone Therapy in St. Louis, Missouri
What Is Prolozone Therapy?
Prolozone is a highly effective regenerative injection technique developed from the principles of ozone therapy and prolotherapy. It involves injecting a combination of:
- Medical-grade ozone (O₃)
- B vitamins and minerals
- Amino acids or homeopathic anti-inflammatory compounds
- Rebuilding nutrients that support ligament and cartilage repair
The goal of this treatment is to enhance tissue oxygenation and stimulate cellular regeneration within joints, ligaments, tendons, and surrounding soft tissues. While traditional injections (like corticosteroids) only provide temporary relief, Prolozone addresses the root causes of pain, such as poor circulation, tissue degeneration, and chronic inflammation.
How Prolozone Works
Restores Oxygen Flow to Damaged Tissues
Ozone increases the amount of oxygen available to the cells. Oxygen is essential for mitochondrial function, energy production, and tissue repair. With improved oxygenation, the environment becomes ideal for healing.
Activates Cellular Energy and Metabolic Function
By enhancing mitochondrial activity, Prolozone helps cells produce more energy (ATP), accelerating repair processes in ligaments, tendons, cartilage, and surrounding tissues.
Strengthens Ligaments & Rebuilds Connective Tissue
Ligament laxity is a major, often overlooked contributor to joint pain and instability. The nutrient solution used in Prolozone helps activate fibroblasts, the cells responsible for producing collagen, thereby promoting stronger, more stable joint structures.
Stimulates Natural Regeneration
The combination of vitamins, minerals, and ozone stimulates metabolic activity in damaged tissues, leading to:
● Improved cartilage resilience
● Faster tissue repair
● Increased joint stability
● Reduced pain signals
● Enhanced overall function
Together, these tools allow us to personalize your program and give you the best chance for success.
Joint & Degenerative Conditions
- Knee osteoarthritis
- Hip arthritis
- Shoulder arthritis and rotator cuff injuries
- Hand, thumb, and finger arthritis
- Ankle and foot arthritis
Spine-Related Pain
- Chronic low back pain
- Herniated or bulging discs
- Degenerative disc disease
- Sacroiliac (SI) joint dysfunction
- Cervical neck pain
Soft Tissue & Overuse Injuries
- Tendonitis and bursitis
- Tennis elbow and golfer’s elbow
- Plantar fasciitis
- Achilles tendon injuries
- Carpal tunnel syndrome
Neuromuscular & Chronic Pain Conditions
- Sciatica
- Fibromyalgia flare areas
- TMJ pain
- Myofascial trigger points
What to Expect During Your Appointment
Comprehensive Evaluation
Your visit begins with a detailed assessment to identify the exact source of pain or instability. Our providers use a thorough history, physical examination, and functional assessment to localize areas of weakness or inflammation.
Targeted Nutrient Injection
A customized solution of vitamins, minerals, and tissue-supporting nutrients is injected into the targeted area. This prepares the tissue for ozone and provides essential building blocks for repair.
Ozone and Oxygen Injection
Medical-grade ozone and oxygen are then injected to significantly increase oxygen availability and trigger regenerative healing responses.
Recovery and Aftercare
Most patients experience immediate or gradual relief. You may feel mild soreness for 24–48 hours, but downtime is minimal, and normal activities can usually be resumed the same day. Each session typically takes 15–30 minutes.
How Many Prolozone Treatments Will I Need?
The number of Prolozone Therapy sessions varies based on the severity of your condition, how long you have experienced symptoms, and your overall health.
- Many patients notice improvement after 1–3 treatments
- Chronic or advanced degenerative conditions may require 4–6 sessions
- Treatments are typically spaced several weeks apart
Regenerative benefits often continue to develop over time, providing lasting improvements in pain and function.
Benefits of Prolozone Therapy
Non-Surgical and Minimally Invasive
No incisions, no general anesthesia, and no prolonged recovery period.
Treats the Root Cause of Pain
Rather than masking symptoms, Prolozone strengthens weakened tissue and improves joint stability.
Reduces Dependence on Medications
Many patients are able to reduce or avoid steroids, NSAIDs, or opioid pain medications.
Improves Mobility and Function
By restoring oxygen flow and connective tissue strength, patients often experience better movement and stability.
Supports Long-Term Healing
Ozone activates natural biological repair pathways that continue working beyond the treatment session.
Ready to Get Relief? Schedule Your Prolozone Consultation
Living with chronic pain doesn’t have to be your normal. If joint, spine, or soft tissue pain is limiting your daily activities, Prolozone Therapy may offer a non-surgical path to long-term relief.
At Health by Design MD, we begin with a comprehensive evaluation to determine whether Prolozone Therapy is the right option for your condition.
Frequently Asked Questions About Prolozone Therapy
What conditions respond best to Prolozone Therapy?
Prolozone Therapy is highly effective for joint pain, arthritis, neck and back pain, rotator cuff injuries, knee degeneration, plantar fasciitis, tendonitis, sciatica, TMJ pain, and many chronic musculoskeletal conditions that have not responded well to medications, physical therapy, or steroid injections.
How soon will I see results?
Some patients experience improvement after the first or second treatment. Pain reduction typically continues over several weeks as tissue repair progresses. Chronic conditions may require additional sessions for optimal results.
How many treatments will I need?
Most patients need between 1 and 3 sessions. More advanced or long-standing degenerative issues may require 4 to 6 treatments. Your provider will recommend a personalized plan.
Is Prolozone Therapy painful?
Most patients tolerate Prolozone injections well. You may feel brief pressure or mild discomfort during treatment, followed by temporary soreness that resolves within 24–48 hours.
How is Prolozone different from steroid injections?
Steroid injections suppress inflammation temporarily and may weaken tissue over time. Prolozone Therapy improves oxygen delivery, supports tissue regeneration, and strengthens ligaments and joints naturally.